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Osteoporosis : exploring characteristics amongst non-Hispanic Black women associated with low bone mass (ostepenia) and osteoporosis, who are thus more likely to suffer osteoporotic injuries in the future
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Title
Osteoporosis : exploring characteristics amongst non-Hispanic Black women associated with low bone mass (ostepenia) and osteoporosis, who are thus more likely to suffer osteoporotic injuries in the future
Name
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Everett
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Sharlette
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Everett, Sharlette
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author
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Coffman
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Frederick D
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Frederick D Coffman
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Advisory Committee
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chair
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Sirinivasan
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Shankar
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Shankar Sirinivasan
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Advisory Committee
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internal member
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Taylor
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Stephanie
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Stephanie Taylor
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Advisory Committee
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Rutgers University
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School of Health Professions
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theses
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2020
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2020-08
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English
Abstract
Non-Hispanic Black women have higher bone mass and lower rates of osteoporosis; however, age-related bone loss occurs at rates equal to other races. Osteopenia or osteoporotic occurs at greater age for non-Hispanic black women and may increase their risk of poor outcomes post an osteoporotic injury. It is important to determine what clinical characteristics or assessment standards to use to predict who may be more likely to develop osteopenia or osteoporosis in this population.
A retrospective database analysis of NHANES 4-year survey cycle: 2007-208 and 2009-2010 to examine characteristics associated with low bone mass and osteoporosis in non-Hispanic Black females aged 20 and older. Evaluation of standard bone mineral density (BMD) T-scores compared to mean referent value for young, healthy non-Hispanic black females BMD scores.
A total of 190 (20.7%) non-Hispanic Black females had osteopenia or osteoporosis compared to 770 (32.3%) non-Hispanic white females(p<.0001). Among non-Hispanic Black females, osteopenia and osteoporosis were associated with being aged 50 or older (ORadj = 2.8, p=0.0003), less than a high school education (ORadj = 1.6, p=0.02) and menopause (ORadj = 2.0, p=0.0036). Osteopenia or osteoporosis was less likely if obese (ORadj = 0.5, p=0.003). Each increased year in age, total femur BMD declined 0.43 points (<.0001) and 0.38 points (<.0001) for spinal BMD. When the non-Hispanic Black referent was used, 91 (9.9%) had BMD classifications that worsen to osteopenia or osteoporosis: they were older (p<.0001), menopausal (p<.001), not obese (p<.001), experienced a hip fracture (p<.0001), taking diabetes (p<.001) or cardiovascular medication (p<.01) or had a close relative with asthma (p<.001).
Calculation of BMD T-score using the referent mean value for young (20-29-year-olds), healthy non-Hispanic Black females instead of the standard for non-Hispanic white females were more sensitive in detecting additional individuals with low bone mass (osteopenia) or osteoporosis. Use of the standardized BMD and FRAX may be of limited utility in distinguishing those within a low-risk population, who may be at greater risk. Use of a non-Hispanic Black specific measure may lead to earlier detection and intervention in this population.
A retrospective database analysis of NHANES 4-year survey cycle: 2007-208 and 2009-2010 to examine characteristics associated with low bone mass and osteoporosis in non-Hispanic Black females aged 20 and older. Evaluation of standard bone mineral density (BMD) T-scores compared to mean referent value for young, healthy non-Hispanic black females BMD scores.
A total of 190 (20.7%) non-Hispanic Black females had osteopenia or osteoporosis compared to 770 (32.3%) non-Hispanic white females(p<.0001). Among non-Hispanic Black females, osteopenia and osteoporosis were associated with being aged 50 or older (ORadj = 2.8, p=0.0003), less than a high school education (ORadj = 1.6, p=0.02) and menopause (ORadj = 2.0, p=0.0036). Osteopenia or osteoporosis was less likely if obese (ORadj = 0.5, p=0.003). Each increased year in age, total femur BMD declined 0.43 points (<.0001) and 0.38 points (<.0001) for spinal BMD. When the non-Hispanic Black referent was used, 91 (9.9%) had BMD classifications that worsen to osteopenia or osteoporosis: they were older (p<.0001), menopausal (p<.001), not obese (p<.001), experienced a hip fracture (p<.0001), taking diabetes (p<.001) or cardiovascular medication (p<.01) or had a close relative with asthma (p<.001).
Calculation of BMD T-score using the referent mean value for young (20-29-year-olds), healthy non-Hispanic Black females instead of the standard for non-Hispanic white females were more sensitive in detecting additional individuals with low bone mass (osteopenia) or osteoporosis. Use of the standardized BMD and FRAX may be of limited utility in distinguishing those within a low-risk population, who may be at greater risk. Use of a non-Hispanic Black specific measure may lead to earlier detection and intervention in this population.
Subject
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Topic
Osteoporosis
Subject
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Topic
Biomedical Informatics
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Rutgers University Electronic Theses and Dissertations
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Ph.D.
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Includes bibliographical references
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School of Health Professions ETD Collection
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doi:10.7282/t3-21wb-k326
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ETD doctoral
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Rights
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The author owns the copyright to this work.
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Name
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Everett
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Sharlette
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Permission or license
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2020-05-19 21:24:10
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Sharlette Everett
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Rutgers University. School of Health Professions
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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2020-08-31
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2021-08-31
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Access to this PDF has been restricted at the author's request. It will be publicly available after August 31st, 2021.
Copyright
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Copyright protected
Availability
Status
Open
Reason
Permission or license
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