A comparative study for hospitalization characteristics and predictors of Covid-19 inpatients in the United States
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Ali, Ryad A..
A comparative study for hospitalization characteristics and predictors of Covid-19 inpatients in the United States. Retrieved from
https://doi.org/doi:10.7282/t3-9g2v-aq98
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TitleA comparative study for hospitalization characteristics and predictors of Covid-19 inpatients in the United States
Date Created2021
Other Date2021-08 (degree)
Extent1 online resource (viii, 130 pages) : illustrations
DescriptionBACKGROUND:
In 2021, the world is still in the midst of the Covid-19 pandemic. Many aspects of Covid-19 related to transmission, infection, and treatment still remain unclear. Severe obesity increases the risk for negative outcomes in patients with Coronavirus Disease 2019 (COVID-19). The objectives of this study were to investigate the effect of BMI on in-hospital outcomes in the New York City Health and Hospitals ethnically diverse population, explore further this effect by age, sex, race/ethnicity, and timing of admission, and given the relationship between COVID-19 and hyperinflammation assess the concentrations of markers of systemic inflammation in different BMI groups.
METHOD:
This was a retrospective study of consecutive hospitalized patients with COVID-19 in the public health care system of New York City from March 1st, 2020 to October 31st, 2020. In total, 8833 patients were included in this analysis. Results of logistic regression are given as the odds ratio (OR) with the 95% confidence interval (CI). The threshold of statistical significance was p <0.05. All analyses were performed using SAS software (Release 9.4M6; SAS Institute, USA).
RESULTS:
8833 patients were included in this analysis (women: 3593, median age: 62 years). The median body mass index (BMI) was 27.9 kg/m2. Both overweight and obesity were independently associated with in-hospital death (BMI 25 to <30 kg/m2: OR 1.220, 95% CI: 1.068-1.393; BMI 30 to <35 kg/m2: OR 1.494, 95% CI: 1.278-1.746; BMI 35 to <40 kg/m2: OR 2.164, 95% CI: 1.780-2.632), and BMI ≥40 kg/m2: OR 2.242, 95% CI: 1.855-2.710). The association of overweight and obesity with death appeared to be stronger in men, older patients, and individuals of Hispanic ethnicity. In this study, higher concentrations of inflammatory markers in patients with obesity as compared to those without obesity were not observed.
CONCLUSION:
It was observed that overweight and obesity were associated with in-hospital death, admission to ICU, and invasive mechanical ventilation after adjusting for obesity-related potentially confounding factors. The association of overweight and obesity with death appeared to be stronger in men, older patients, and individuals of Hispanic ethnicity. Patients with obesity did not have higher concentrations of inflammatory markers on presentation. CRP, IL-6, ferritin, LDH, and D-dimer were positively associated with death, while albumin and monocytes were inversely associated with death after adjusting for age, sex, and BMI.
NotePh.D.
NoteIncludes bibliographical references
Genretheses
LanguageEnglish
CollectionSchool of Health Professions ETD Collection
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.