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Patient’s perceptions and motivation related to preimplantation genetic testing for polygenic conditions

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TitleInfo
Title
Patient’s perceptions and motivation related to preimplantation genetic testing for polygenic conditions
Name (type = personal)
NamePart (type = family)
Reynolds
NamePart (type = given)
Kelsey Christine
DisplayForm
Kelsey Christine Reynolds
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Seymour
NamePart (type = given)
Christine
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Christine Seymour
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Advisory Committee
Role
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chair
Name (type = personal)
NamePart (type = family)
Eccles
NamePart (type = given)
Jennifer
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Jennifer Eccles
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Advisory Committee
Role
RoleTerm (authority = local)
member
Name (type = personal)
NamePart (type = family)
Treff
NamePart (type = given)
Nathan
DisplayForm
Nathan Treff
Affiliation
Advisory Committee
Role
RoleTerm (authority = local)
member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact); (keyDate = yes)
2022
DateOther (encoding = w3cdtf); (type = degree); (qualifier = exact)
2022-05
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract (type = abstract)
For years couples undergoing in vitro fertilization (IVF) have been able to access preimplantation genetic testing (PGT) for aneuploidy, chromosomal rearrangements, and monogenic conditions. Screening embryos for polygenic conditions such as diabetes, cancer and cardiovascular risk has not been available until more recent years. PGT for polygenetic conditions (PGT-P) has been made possible with advancements in technology and increasing available data from genome wide association studies (GWAS). As is common with new technology, there has been push back from some calling its use controversial, however many patients have opted into this technology with hopes that it would provide them useful information when selecting an embryo to transfer and allow them to transfer the healthiest embryo possible. Our research investigates these patients’ motivations to use PGT-P and the decision-making factors that they considered during this process. Our study found that the PGT-P result was a valuable tool for our patients as it was ranked highly when selecting an embryo to transfer. Additionally, patients had minimal feelings of decision regret upon reflecting on their decision to opt into PGT-P. This provides the first source of data directly from patients that have used the technology and is exciting insight into the patient experience with PGT-P.
Subject (authority = RUETD)
Topic
Genetics
Subject (authority = LCSH)
Topic
Preimplantation genetic diagnosis
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
http://dissertations.umi.com/gsnb.rutgers:11912
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application/pdf
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text/xml
Extent
38 pages : illustrations
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/t3-n5bh-ka97
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Reynolds
GivenName
Kelsey
Role
Copyright holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2022-06-07T11:22:03
AssociatedEntity
Name
Kelsey Reynolds
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2022-03-20T14:11:56
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2022-03-20T14:11:56
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