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I. Prodrugs based on the sulfamate linkage II. Seleninic acids as biomimetic enzyme inhibitors
Descriptive
TitleInfo
Title
I. Prodrugs based on the sulfamate linkage II. Seleninic acids as biomimetic enzyme inhibitors
TitleInfo
(type = alternative)
Title
Seleninic acids as biomimetic enzyme inhibitors
Name
(type = personal)
NamePart
(type = family)
Sun
NamePart
(type = given)
Zhexun
NamePart
(type = date)
1987-
DisplayForm
Zhexun Sun
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Knapp
NamePart
(type = given)
Spencer
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Spencer Knapp
Affiliation
Advisory Committee
Role
RoleTerm
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chair
Name
(type = personal)
NamePart
(type = family)
Williams
NamePart
(type = given)
Lawence
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Lawence Williams
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Jimenez
NamePart
(type = given)
Lesilie
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Lesilie Jimenez
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
Graduate School - New Brunswick
Role
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school
TypeOfResource
Text
Genre
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theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-10
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The most important two features of a successful drug are the biochemical effects of active pharmaceutical ingredients and the efficacy of their delivery methods. Synthetic organic chemistry plays crucial roles in virtually both of these aspects for the design and the development of new drugs. Herein, in the first half part of the dissertation, a novel synthesis strategy of sulfamate esters is developed, which has been successfully applied into the synthesis of several tripartate pro-drugs with the purpose of improving the delivery efficiency of ethinyl estradiol. Their pharmaceutical effects are evaluated by both in vitro and in vivo studies as described. In the second half part, novel synthesis of several biomimetic enzyme inhibitors, including selenoxide, diselenide, seleninic acid, and various other organoselenium compounds is reported. Evaluation of these biomimetics will be elucidated in the future.
Subject
(authority = RUETD)
Topic
Chemistry and Chemical Biology
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
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ETD_4265
PhysicalDescription
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electronic resource
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application/pdf
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text/xml
Extent
x, 89 p. : ill.
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Zhexun Sun
Subject
(authority = ETD-LCSH)
Topic
Prodrugs
Subject
(authority = ETD-LCSH)
Topic
Enzyme inhibitors
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000066995
RelatedItem
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
(type = doi)
doi:10.7282/T38P5Z8J
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Sun
GivenName
Zhexun
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2012-09-22 11:25:43
AssociatedEntity
Name
Zhexun Sun
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
DateTime
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(qualifier = exact);
(point = start)
2012-10-31
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = end)
2013-05-02
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 2nd, 2013.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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