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Novel perspectives in cancer chemoprevention via Nrf2 pathway
Descriptive
TitleInfo
Title
Novel perspectives in cancer chemoprevention via Nrf2 pathway
SubTitle
from pharmacogenomics to pharmacoepigenetics
Name
(type = personal)
NamePart
(type = family)
Wu
NamePart
(type = given)
Tien-Yuan
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Tien-Yuan Wu
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author
Name
(type = personal)
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KONG
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(type = given)
AH-NG
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AH-NG KONG
Affiliation
Advisory Committee
Role
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chair
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(type = personal)
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(type = family)
Chen
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(type = given)
Suzie
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Suzie Chen
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Suh
NamePart
(type = given)
Nanjoo
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Nanjoo Suh
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Androulakis
NamePart
(type = given)
Ioannis P.
DisplayForm
Ioannis P. Androulakis
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
outside member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
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(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2012
DateOther
(qualifier = exact);
(type = degree)
2012-10
CopyrightDate
(qualifier = exact)
2012
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
The cancer chemoprevention is the strategy of blocking or slowing the onset of premalignant tumors and decreases the incidence of cancer with relatively nontoxic chemical substance. More importantly, Nrf2 and Nrf2-antioxidant response element (ARE) pathway plays a critical role in the cancer chemoprevention. Studies of the induction of Nrf2 and subsequent phase II detoxifying/antioxidant drug metabolism enzymes expression by phytochemicals in vivo or in vitro are considered as a major topic. This thesis will focus on the factors important in the regulation of Nrf2 and phase II xenobiotic metabolizing enzymes which are generally considered as antioxidant and detoxifying enzymes in cancer chemoprevention. Accumulating evidence from epidemiological studies indicates that chronic inflammation and oxidative stress play critical roles in neoplastic development. Our results show that tea Chrysanthemun zawadskii (CZ) and licorice Glycyrrhiza uralensis (LE) extracts exhibited potent anti-inflammatory activities by suppressing the mRNA and protein expression levels of pro-inflammatory biomarkers and the NF-kB luciferase activity. Both extracts also showed strong inhibitory effects against NF-kB-mediated inflammatory as well as strong activation of the Nrf2-ARE-antioxidative stress signaling pathways. Indole-3-carbinol (I3C) and its acid condensation product, 3,3’-diindolylmethane (DIM) were examined the chemopreventive effect and the molecular mechanism, particularly the anti-oxidative stress pathway regulated by Nrf2, in transgenic adenocarcinoma of mouse prostate (TRAMP) mice and TRAMP C1 cells. I3C and DIM significantly suppressed the incidence of palpable tumor (p<0.05) and reduced the genitourinary weight (p<0.05) and induced Nrf2 and related genes expression in TRAMP mice. DIM can also epigenetically modify the CpG methylation status of Nrf2 in vivo and in vitro, and enhanced expression of Nrf2 and Nrf2-mediated genes. Using dietary phytochemicals to modulate the genomic as well as epigenomic is thought to be plausible in cancer chemoprevention in the future.
Subject
(authority = RUETD)
Topic
Pharmaceutical Science
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_4325
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
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text/xml
Extent
xvi, 151 p. : ill.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = vita)
Includes vita
Note
(type = statement of responsibility)
by Tien-Yuan Wu
Subject
(authority = ETD-LCSH)
Topic
Cancer--Chemoprevention
Subject
(authority = ETD-LCSH)
Topic
Phytochemicals
Subject
(authority = ETD-LCSH)
Topic
Pharmacogenomics
Identifier
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http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000067028
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
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doi:10.7282/T37S7MJG
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Wu
GivenName
Tien-Yuan
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2012-09-29 12:59:41
AssociatedEntity
Name
Tien-Yuan Wu
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
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2012-10-31
DateTime
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2013-10-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2013.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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