DescriptionThis dissertation deals with real life inventory and supply chain management problems. Three chapters are dedicated to di fferent problems, two of them dealing with vessel scheduling and container management, where as the last one deal with inventory management of critical supplies at hospitals, during time of surging demand. We propose heuristics and exact approaches for these problems that are both e fficient in terms of time, and accurate enough to our needs. Even though inventory and supply chain management fi eld is a popular fi eld of research, these problems have not been addressed yet, and known results cannot be directly applied to any of them.