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Design and characterization of the tensile properties of 3-d braid-twist ligament scaffolds
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Rao, Rohit. Design and characterization of the tensile properties of 3-d braid-twist ligament scaffolds. Retrieved from https://doi.org/doi:10.7282/T3MS3VGC

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TitleDesign and characterization of the tensile properties of 3-d braid-twist ligament scaffolds
NameRao, Rohit (author); Freeman, Joseph W (chair); Dunn, Michael G (internal member); Olabisi, Ronke (internal member); Rutgers University; Graduate School - New Brunswick
Date Created2015
Other Date2015-01 (degree)
SubjectBiomedical Engineering, Tissue engineering, Joints--Regeneration, Anterior cruciate ligament
Extent1 online resource (vi, 30 p. : ill.)
DescriptionThere are roughly between 100,000 -250,000 anterior cruciate ligament (ACL) injuries that are annually diagnosed in the U.S. alone. Around 50,000 of these require surgical reconstruction and replacement of the ACL [1-2]. The current treatment of choice is the use of an autograft harvested from the patellar tendon, the hamstring tendon or quadriceps tendons. However, autologous grafts are associated with a number of drawbacks including donor site morbidity and the requirement of two surgeries to carry out the ACL replacement. Therefore, alternative techniques need to be developed for ACL reconstruction. Recently tissue engineering-based scaffolds have received wide attention as potentially viable alternatives to autografts. This report discusses the development and characterization of the tensile properties of a 3-D braid twist scaffold fabricated using an automated braiding machine. The braiding angle of the scaffolds was altered in a controllable manner. Scaffolds with three different braiding angles; 53°, 63° and 72° were obtained to determine the effect of braiding angle on the tensile properties of the braid-twist scaffolds. Based on these studies scaffolds with a braiding angle of 72° were determined to have tensile characteristics most suitable for ligament replacement. Future studies will further evaluate the mechanical and biological properties of these scaffolds.
NoteM.S.
NoteIncludes bibliographical references
Noteby Rohit Rao
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3MS3VGC
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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