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A fluorescence spectroscopy and fluorescence anisotropy investigation of the heteroaggregation of alginate microparticles and chitosan nanoparticles
Descriptive
TitleInfo
Title
A fluorescence spectroscopy and fluorescence anisotropy investigation of the heteroaggregation of alginate microparticles and chitosan nanoparticles
Name
(type = personal)
NamePart
(type = family)
Pathak
NamePart
(type = given)
Chinmay
NamePart
(type = date)
1990-
DisplayForm
Chinmay Pathak
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Shapley
NamePart
(type = given)
Nina
DisplayForm
Nina Shapley
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Chiew
NamePart
(type = given)
Yee
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Yee Chiew
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Dutt
NamePart
(type = given)
Meenakshi
DisplayForm
Meenakshi Dutt
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2015
DateOther
(qualifier = exact);
(type = degree)
2015-05
CopyrightDate
(encoding = w3cdtf);
(qualifier = exact)
2015
Place
PlaceTerm
(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Heteroaggregation is the aggregation in a mixed particle system where particles differ in size, chemical composition and charge. This heteroaggregation phenomenon has great importance in the natural environment as well as in industrial processes. The heteroaggregates have a wide range of applications such as particle stabilization, drug delivery and encapsulation. Previous studies of heteroaggregates have involved rigid spherical particles. In this work, we have used hydrophilic hydrogel particles which are oppositely charged and soft. These hydrogel particles, in particular, chitosan and alginate, have gained interest due to their biodegradability and nontoxicity as well as multiple delivery mechanisms. This study focuses on understanding the heteroaggregation behavior of chitosan nanoparticles and alginate microparticles and several factors affecting their interaction. Fluorescence spectroscopy was used to characterize and identify boundaries between several heteroaggregate morphologies, or “phases,” in the system of chitosan nanoparticles and alginate microparticles. Optical microscopy was used to observe the aggregate phases formed by fluorescently tagged chitosan nanoparticles mixed with alginate microparticles. The effect of the concentration ratio of alginate microparticles and chitosan nanoparticles was also explored. Next, the interaction between these particles was studied for varying pH of the system as pH is an important factor where micro- and nanoparticles are used as a drug delivery system. The interaction behavior was examined regarding the changes in solution ionic strength. Furthermore, fluorescence anisotropy, which is correlated to mobility, was used to observe aggregates’ formation with varying concentration and pH. Finally, fluorescence spectroscopy was performed in situ in a vial containing an alginate-chitosan system.
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject
(authority = ETD-LCSH)
Topic
Chitosan
Subject
(authority = ETD-LCSH)
Topic
Nanoparticles
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
(type = RULIB)
ETD
Identifier
ETD_6326
PhysicalDescription
Form
(authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xv, 112 p. : ill.)
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Chinmay Pathak
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T38S4RR0
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Pathak
GivenName
Chinmay
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
(encoding = w3cdtf);
(qualifier = exact);
(point = start)
2015-04-13 02:15:47
AssociatedEntity
Name
CHINMAY PATHAK
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
(ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem
(VERSION = 5.1)
windows xp
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