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Process systems engineering methods for the development of continuous pharmaceutical manufacturing processes
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Rogers, Amanda. Process systems engineering methods for the development of continuous pharmaceutical manufacturing processes. Retrieved from https://doi.org/doi:10.7282/T37H1MGJ

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TitleProcess systems engineering methods for the development of continuous pharmaceutical manufacturing processes
NameRogers, Amanda (author); Ierapetritou, Marianthi G (chair); Muzzio, Fernando (internal member); Ramachandran, Rohit (internal member); Tabora, Jose (outside member); Rutgers University; Graduate School - New Brunswick
Date Created2015
Other Date2015-05 (degree)
SubjectChemical and Biochemical Engineering, Pharmaceutical industry--Quality control, Manufacturing processes, Pharmaceutical chemistry
Extent1 online resource (xii, 170 p. : ill.)
DescriptionThe objective of this dissertation is to develop mathematical methods to assist in the development of continuous processes for the manufacture of pharmaceutical drug products. Specifically, modeling, analysis and optimization techniques will be developed in order to apply concepts from the field of process systems engineering to pharmaceutical development. These concepts, including sensitivity analysis, feasibility and flexibility analysis and optimal design under uncertainty, can contribute to the development of robust and well-understood manufacturing processes. This is consistent with the aim Quality-by-Design in the pharmaceutical process development. Throughout this dissertation, case studies related to continuous solids-based manufacturing will be used to demonstrate the role that process systems engineering can play in process development. The mathematical methods introduced in this dissertation will emphasize the use of reduced-order and surrogate models to address the unique challenges associated with modeling, analysis and optimization of solids-based processes.
NotePh.D.
NoteIncludes bibliographical references
Noteby Amanda Rogers
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T37H1MGJ
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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