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Effect of staphylococcal enterotoxin A (SEA) on cell proliferation in the dentate gyrus and hippocampal-dependent learning and memory
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Chang, Qing. Effect of staphylococcal enterotoxin A (SEA) on cell proliferation in the dentate gyrus and hippocampal-dependent learning and memory. Retrieved from https://doi.org/doi:10.7282/T34B338R

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TitleEffect of staphylococcal enterotoxin A (SEA) on cell proliferation in the dentate gyrus and hippocampal-dependent learning and memory
NameChang, Qing (author); Kusnecov, Alexander (chair); Wagner, George (internal member); Shors, Tracey (internal member); Rutgers University; Graduate School - New Brunswick
Date Created2015
Other Date2015-10 (degree)
SubjectPsychology, Staphylococcal protein A
Extent1 online resource (vi, 40 p. : ill.)
DescriptionStaphylococcal enterotoxin A (SEA) is known as a T cell superantigen, with well-characterized neurobiological and endocrine effects. We have quantified the survival of new cells, labeled with BrdU, in the dentate gyrus of the hippocampus after SEA or Saline injection into male C57BL/6 mice. A reduction of BrdU+ cells was found on Day 11 after SEA treatment, but not on Day 4. This suggests that BrdU+ cell retention was reduced by T cell activation. To determine if this decline in BrdU+ cells might predict deficits in spatial learning, a second experiment was conducted in which the effect of SEA treatment on spatial navigation learning in the Morris water maze (MWM) and the water-based Radial Arm Maze (wRAM) was investigated. Male C57BL/6J mice were given 5 ug SEA (N=7) or Saline (N=7) and then subjected to MWM hidden platform training. Two weeks after the final MWM training, mice were subjected to 8 days of water-based radial arm maze (wRAM) training. The results showed no major SEA effect on initial MWM learning. Further, wRAM learning was not affected by SEA-treated mice, but interfered with the interaction of SEA treatment and MWM pre-exposure. This may be due to a reduction in cognitive flexibility.
NoteM.S.
NoteIncludes bibliographical references
Noteby Qing Chang
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T34B338R
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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