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pH sensitive liposomes for targeted delivery of antibiotics to localized internal bacterial infection sites
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Rane, Varsha. pH sensitive liposomes for targeted delivery of antibiotics to localized internal bacterial infection sites. Retrieved from https://doi.org/doi:10.7282/T3MS3VV9

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TitlepH sensitive liposomes for targeted delivery of antibiotics to localized internal bacterial infection sites
NameRane, Varsha (author); Sofou, Stavroula (chair); Roth, Charlie (internal member); Androulakis, Ioannis (internal member); Rutgers University; Graduate School - New Brunswick
Date Created2016
Other Date2016-01 (degree)
SubjectChemical and Biochemical Engineering, Liposomes, Antibiotics, Drug delivery systems
Extent1 online resource (vii, 32 p. : ill.)
DescriptionMethicillin Resistant Staphylococcus aureus (MRSA) causes a myriad of infections ranging from mild skin-infection to more serious infections affecting internal organs. A glycopeptide, Vancomycin, remains the last line of defense against MRSA. The aim of this study is to investigate whether liposomal encapsulated Vancomycin had a better antimicrobial action than free Vancomycin in terms of infection-specific targeting and circulation time. For the same, encapsulation efficiency and release kinetics of the liposomes was evaluated along with Minimum Inhibitory Concentrations (MIC) of the liposomal preparations. The liposomes showcased a 12-15% encapsulation efficiency. Sustained release at pH 6.0 as compared to little to no release at pH 7.4 was demonstrated by the pH sensitive liposomes. Also, in acidic pH, an increase in efficacy was observed with a greater decrease in the MIC of the pH responsive liposomes as compared to the lower decrease in MIC of the non pH-responsive liposomes and increase in MIC of free Vancomycin. Thus, from the results it can be concluded that environmentally sensitive liposomes could be developed as a successful carrier of antimicrobial drugs demonstrating effective antimicrobial action.
NoteM.S.
NoteIncludes bibliographical references
Noteby Varsha Rane
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3MS3VV9
Languageeng
CollectionGraduate School - New Brunswick Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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