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Advanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications
Descriptive
TitleInfo
Title
Advanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications
Name
(type = personal)
NamePart
(type = family)
Dube
NamePart
(type = given)
Koustubh Shishir
NamePart
(type = date)
1986-
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Koustubh Shishir Dube
Role
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(authority = RULIB)
author
Name
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Kohn
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Joachim
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Joachim Kohn
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Advisory Committee
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chair
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Rutgers University
Role
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degree grantor
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Graduate School - New Brunswick
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theses
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2017
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2017-01
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2017
Place
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xx
Language
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eng
Abstract
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Advances in biomaterials can be brought about by the development of novel polymers that are designed to satisfy multiple criteria. Some of these criteria are biodegradability, biocompatibility, processability to fabricate into different architectures, and appropriate mechanical properties. Modifying currently existent polymeric biomaterials only gives limited control over desired properties; these properties can be easily tuned when new polymers are designed. One important aspect for the advancement of biomaterials is the ability to functionalize them by attaching biomolecules to create or enhance the regenerative response in the body. While such reactivity is actively being explored in soft polymeric biomaterials such as hydrogels, bioconjugation of biomolecules to stiff polymers has not been investigated. In this dissertation, the synthesis and properties of novel polymers synthesized from naturally occurring molecules such as tyrosol and 2-(4-hydroxyphenyl)acetic acid are reported. The polymers were incorporated with pendant chemical groups that can undergo ‘click’ reactions under physiological conditions. The reactivity of the polymers towards thiol containing small molecule, thiol containing proteins, and proteins and polysaccharides modified with azide group is reported. It was discovered that it is possible to fabricate the designed polymers into computer-aided architectures by fused deposition modeling. Additionally, in this thesis, the structure-property relationship of polycarbonates derived from diesters of 2-(4-hydroxyphenyl)acetic acid and 2-(4-hydroxyphenyl)propionic acid with alkane diols are explored in Chapter 5. The striking difference in thermal and mechanical properties by a small change in the chemical composition of the monomer is noted. Finally, independent research work done on tyrosine-derived polycarbonates is presented in Appendix 1 and 2.
Subject
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Topic
Chemistry and Chemical Biology
Subject
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Topic
Biomedical materials
Subject
(authority = ETD-LCSH)
Topic
Polymers
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Rutgers University Electronic Theses and Dissertations
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ETD_7757
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electronic resource
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application/pdf
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Extent
1 online resource (xxiii, 152 p. : ill.)
Note
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Ph.D.
Note
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Includes bibliographical references
Note
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by Koustubh Shishir Dube
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
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doi:10.7282/T37S7R6N
Genre
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ETD doctoral
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Dube
GivenName
Koustubh
MiddleName
Shishir
Role
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Permission or license
DateTime
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2016-11-08 17:06:59
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Koustubh Dube
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Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
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Copyright protected
Availability
Status
Open
Reason
Permission or license
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2016-11-08T22:00:03
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2016-11-08T22:00:03
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