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Discerning the effect of salt, riboflavin and MTHFR on acute blood pressure response
Descriptive
TitleInfo
Title
Discerning the effect of salt, riboflavin and MTHFR on acute blood pressure response
Name
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(type = family)
Murphy
NamePart
(type = given)
Melissa Anne
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(type = date)
1983-
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Melissa Anne Murphy
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(authority = RULIB)
author
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(type = personal)
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(type = family)
Miller
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(type = given)
Joshua W.
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Joshua W. Miller
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Advisory Committee
Role
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chair
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Breslin
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Paul A.S.
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Paul A.S. Breslin
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Advisory Committee
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co-chair
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(type = family)
Shapses
NamePart
(type = given)
Sue A.
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Sue A. Shapses
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Advisory Committee
Role
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internal member
Name
(type = personal)
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(type = family)
Bello
NamePart
(type = given)
Nicholas T.
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Nicholas T. Bello
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Gow
NamePart
(type = given)
Andrew W.
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Andrew W. Gow
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Advisory Committee
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(authority = RULIB)
outside member
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Rutgers University
Role
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(authority = RULIB)
degree grantor
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Graduate School - New Brunswick
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school
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Text
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theses
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2017
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2017-05
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2017
Place
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xx
Language
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eng
Abstract
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Problem: Elevated blood pressure (BP) is a top cause of mortality and leads to millions of global deaths each year; yet the cause of general hypertension (HTN) is not known. Many studies link dietary factors, particularly high sodium levels, with HTN and related cardiovascular diseases. Other studies have identified certain genes, including methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism, with a greater risk of developing HTN. Hypothesis: These studies sought to identify the impact of MTHFR genotype on the acute BP response to salt ingestion. We hypothesized that individuals would have a greater decrease in BP following salt ingestion compared to water and that this response would be diminished by the MTHFR 677TT variant allele. Methods: In an initial cohort, acute BP response was assessed, multiple times per subject, in a series of time points following an ingestion of salt or water. A secondary cohort was formed of individuals with MTHFR677 genotypes whose BP and blood were collected. Blood samples were analyzed for plasma riboflavin, homocysteine, MTHFR genotype and nitrate/nitrite levels. These data were analyzed for differences in BP response, genotypes, micronutrient status and for associations between subjects’ characteristics and BP response. Results: BP decreases within the first 60 minutes following salt ingestion. When measuring resting BP, no difference was found in BP between MTHFR genotypes. However, individuals with the 677TT variant genotype demonstrated an attenuated acute BP response to salt ingestion compared to individuals with the wild-type 677CC genotype. Conclusions: BP decreases acutely in response to salt ingestion. The MTHFR 677TT variant genotype was not associated with elevated resting BP. However, measuring acute BP response illustrated a limited response in the MTHFR variant genotype compared with the wild-type MTHFR genotype. These findings suggest that acute BP response may be a useful measure of a dynamic system, highlighting characteristics that are risk factors for HTN.
Subject
(authority = RUETD)
Topic
Nutritional Sciences
Subject
(authority = ETD-LCSH)
Topic
Blood pressure
Subject
(authority = ETD-LCSH)
Topic
Hypertension
Subject
(authority = ETD-LCSH)
Topic
Methylenetetrahydrofolate reductase
RelatedItem
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Rutgers University Electronic Theses and Dissertations
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ETD_8007
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electronic resource
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application/pdf
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text/xml
Extent
1 online resource (xii, 121 p. : ill.)
Note
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Ph.D.
Note
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Includes bibliographical references
Note
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by Melissa Anne Murphy
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TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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NjNbRU
Identifier
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doi:10.7282/T3251N31
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Murphy
GivenName
Melissa
MiddleName
Anne
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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2017-04-13 11:33:44
AssociatedEntity
Name
MELISSA MURPHY
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
AssociatedObject
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License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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2017-05-31
DateTime
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2018-05-31
Type
Embargo
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 31st, 2018.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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windows xp
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2017-04-21T12:15:35
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2017-04-21T12:15:35
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