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ZAG-1, a Zn-finger homeodomain transcription factor, affects neuronal outgrowth patterning by regulating UNC-40(DCC)-mediated outgrowth activity
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Al-Aamiri, Aseel. ZAG-1, a Zn-finger homeodomain transcription factor, affects neuronal outgrowth patterning by regulating UNC-40(DCC)-mediated outgrowth activity. Retrieved from https://doi.org/doi:10.7282/T3H41VJ1

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TitleZAG-1, a Zn-finger homeodomain transcription factor, affects neuronal outgrowth patterning by regulating UNC-40(DCC)-mediated outgrowth activity
NameAl-Aamiri, Aseel (author); Wadsworth, William (chair); Rutgers University; School of Graduate Studies
Date Created2017
Other Date2017-10 (degree)
SubjectMicrobiology and Molecular Genetics, Axons
Extent1 online resource (x, 196 p. : ill.)
DescriptionAxon guidance is a fundamental process during animal nervous system development. For neurons to function correctly, they must be wired into their target areas. Several neurodevelopment disorders result from wiring defects. The guidance process is continuous, and outgrowth direction activity may fluctuate across the plasma membrane. We propose this process is statistically dependent. If the probability of axon outgrowth at one site changes then the probability at another site must change. The plasma membrane movement can be modeled by a random walk. Axon guidance process is regulated by many conserved extracellular guidance cues that can act as attractants or repellants, but how these guidance cues are regulated is still being researched. In Caenorhabditis elegans, the UNC-6/Netrin extracellular cue directs neuronal outgrowth. Neuronal response to UNC-6/Netrin is mediated by UNC-40/DCC and UNC-5/UNC5 receptors and the UNC-53/NAV2 cytoplasmic protein. My study provides evidence that links stochasticity with transcriptional regulation of axon guidance to regulate axon orientation at the transcriptional level. ZAG-1, a member of the ZEB family of transcription factors, affects neuronal outgrowth patterning by regulating UNC-40-mediated neuronal outgrowth activity. Understanding the functional relationship between transcription factors and the cell-surface and cytoskeletal proteins that mediate their effects is a current challenge in neurobiology. Here I present evidence that ZAG-1 and UNC-5 regulate UNC-40::GFP localization, axon outgrowth patterning, and the directional bias of axons by regulating the UNC-6/Netrin signaling pathway and UNC-53 activities. unc-5 mutations alter UNC-40::GFP asymmetric localization and axon outgrowth patterning that neurons develop. Genetic interactions suggest that UNC-5 and ZAG-1 act with UNC-53 to regulate axon outgrowth patterning and UNC-40::GFP asymmetric localization in response to extracellular guidance cues.
NotePh.D.
NoteIncludes bibliographical references
Noteby Aseel Al-Aamiri
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T3H41VJ1
Languageeng
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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