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Gaining insight into the maturation of iron-sulfur (FeS) clusters in staphylococcus aureus by determining the role of DUF59 protein, SufT
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Bhatt, Shiven K.. Gaining insight into the maturation of iron-sulfur (FeS) clusters in staphylococcus aureus by determining the role of DUF59 protein, SufT. Retrieved from https://doi.org/doi:10.7282/T3GT5RD3

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TitleGaining insight into the maturation of iron-sulfur (FeS) clusters in staphylococcus aureus by determining the role of DUF59 protein, SufT
NameBhatt, Shiven K. (author); Boyd, Jeffrey M (chair); Barkay, Tamar (internal member); Zylstra, Gerben (internal member); Rutgers University; School of Graduate Studies
Date Created2018
Other Date2018-01 (degree)
SubjectMicrobial Biology
Extent1 online resource (viii, 62 p. : ill.)
DescriptionStaphylococcus aureus is a serious mammalian pathogen. For Staphylococcus aureus to successfully inflict pathogenesis upon a host, it is imperative for it to acquire and effectively utilize iron (Fe). Once Fe is internalized, S. aureus utilizes the SUF system to assemble small inorganic cofactors called iron-sulfur (FeS) clusters. FeS clusters have a wide variety of functions in cells, thus, defective FeS cluster assembly results in global metabolic defects. In addition, FeS cluster synthesis and the assembly of FeS proteins is essential in S. aureus and a number of alternate bacterial pathogens suggesting that it is a viable antimicrobial target. Proteins containing DUF59 domains have roles in FeS cluster assembly and are found throughout Eukarya, Bacteria and Archaea. However, the function of DUF59 remains unknown in S. aureus. We have identified the S. aureus SufT, which is composed solely of the DUF59 domain and demonstrated that it has a role in the maturation of iron-sulfur (FeS) proteins.
NoteM.S.
NoteIncludes bibliographical references
Noteby Shiven K. Bhatt
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3GT5RD3
Languageeng
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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