Staphylococcus aureus is a serious mammalian pathogen. For Staphylococcus aureus to successfully inflict pathogenesis upon a host, it is imperative for it to acquire and effectively utilize iron (Fe). Once Fe is internalized, S. aureus utilizes the SUF system to assemble small inorganic cofactors called iron-sulfur (FeS) clusters. FeS clusters have a wide variety of functions in cells, thus, defective FeS cluster assembly results in global metabolic defects. In addition, FeS cluster synthesis and the assembly of FeS proteins is essential in S. aureus and a number of alternate bacterial pathogens suggesting that it is a viable antimicrobial target. Proteins containing DUF59 domains have roles in FeS cluster assembly and are found throughout Eukarya, Bacteria and Archaea. However, the function of DUF59 remains unknown in S. aureus. We have identified the S. aureus SufT, which is composed solely of the DUF59 domain and demonstrated that it has a role in the maturation of iron-sulfur (FeS) proteins.
Subject (authority = RUETD)
Topic
Microbial Biology
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_8669
PhysicalDescription
Form (authority = gmd)
electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (viii, 62 p. : ill.)
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = statement of responsibility)
by Shiven K. Bhatt
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
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