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One-pot hydrothermally synthesized mesostructured silicas for effective controlled drug-release applications
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Ganti, Anjani. One-pot hydrothermally synthesized mesostructured silicas for effective controlled drug-release applications. Retrieved from https://doi.org/doi:10.7282/T3XS5ZKH

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TitleOne-pot hydrothermally synthesized mesostructured silicas for effective controlled drug-release applications
NameGanti, Anjani (author); Asefa, Tewodros (chair); Dutt, Meenakshi (internal member); Hara, Masanori (internal member); Rutgers University; School of Graduate Studies
Date Created2018
Other Date2018-01 (degree)
SubjectChemical and Biochemical Engineering, Drug delivery systems, Mesoporous materials
Extent1 online resource (viii, 35 p. : ill.)
DescriptionMesoporous silica nanoparticles (MSNs) have captured the interest of researchers worldwide due to their unique properties (e.g., high surface area, uniform pores with tunable pore sizes) and application in various fields such as catalysis, drug delivery systems (DDS), etc. In particular, they offer numerous advantages over traditional nano-based formulations in the development of DDS. However, there are few key challenges involved with developing efficient DDS (such as achieving a high drug loading capacity and cost-effective manufacturing of the DDS). Drug-loaded mesostructured silica nanoparticles are typically synthesized in a two-step fashion – the first step involving synthesis of MSNs and the second step entailing the loading of drug into MSNs via physical adsorption of highly concentrated drug solutions onto the mesoporous framework. The current project aims to synthesize a novel DDS for controlled release antimicrobial drug delivery applications that employs the active drug as template in a facile single-step hydrothermal synthesis process, thereby addressing the above mentioned key challenges. Quaternary ammonium compounds (QACs) have been shown to exhibit broad-spectrum antimicrobial activity. In this work, mesostructured silica nanoparticles were synthesized by employing three different QACs - didecyldimethylammonium chloride (DDAC), cetylpyridinium chloride (CPC) and benzalkonium chloride (BAC) – as templates. Initial surface area measurements by physical adsorption of N2 gas on the three synthesized materials indicated the BAC-templated material to be having a high surface area (ca. 1,500 m2/g). Further characterization tests were carried out on this selected material in order to get a better understanding of its properties and also to investigate its potential usage as a DDS for antimicrobial applications. Drug release studies were carried out at physiologically relevant pH levels (5-8) to demonstrate the pH-responsive controlled release of BAC, and the results have been discussed. Microbiological assays demonstrate a significant time-dependent reduction in Staphylococcus aureus and Salmonella enterica viability.
NoteM.S.
NoteIncludes bibliographical references
Noteby Anjani Ganti
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/T3XS5ZKH
Languageeng
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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