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Investigation of freshwater microalgae parachlorella kessleri as a source of anti-inflammatory natural products
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Villani, Thomas S.. Investigation of freshwater microalgae parachlorella kessleri as a source of anti-inflammatory natural products. Retrieved from https://doi.org/doi:10.7282/T35H7KH7

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TitleInvestigation of freshwater microalgae parachlorella kessleri as a source of anti-inflammatory natural products
NameVillani, Thomas S. (author); Simon, James E (chair); Wu, Qingli (internal member); Kimball, David S (internal member); Ho, Chi Tang (internal member); Gianfanga, Tom (outside member); Rutgers University; School of Graduate Studies
Date Created2018
Other Date2018-01 (degree)
SubjectMedicinal Chemistry, Algae
Extent1 online resource (xxiii, 282 p. : ill.)
DescriptionConsidering the tremendous influence that terrestrial plants have had on the identification of bioactive molecules for the modulation of disease, it comes as a surprise that microalgae, which constitute a larger proportion of biomass on earth than terrestrial plants, have not contributed proportionally to the diverse collection of active compounds in pharmacy. As such, microalgae remain an untapped resource for new structures and activities in medicinal chemistry research. The major reason microalgae remain underrepresented in medicinal chemistry exploration is due to the difficulty of obtaining enough biomass to proceed with biochemical and toxicological evaluation of compounds contained within the biomass. Due to recent developments in aquaculture techniques, the biomass-bottleneck has been lifted, and as such, suitable microalgae for a sophisticated exploration of medicinal properties is now obtainable. Using cutting-edge culturing techniques, Parachlorella kessleri, a common freshwater microalga, was amassed in quantities sufficient to support a thorough investigation of the natural products contained within, respective to biological activities relevant to the modulation of inflammation. This investigation revealed several compounds exhibiting anti-inflammatory activity, including a known galactolipid previously unidentified in P. kessleri, and a novel oxygenated fucoxanthin ester, both compounds exhibiting significant activity in anti-inflammatory assays. This dissertation defense explores the bioactive constituents of P. kessleri with respect to anti-inflammatory properties in great detail.
NotePh.D.
NoteIncludes bibliographical references
Noteby Thomas S. Villani Jr.
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/T35H7KH7
Languageeng
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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