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Investigation of freshwater microalgae parachlorella kessleri as a source of anti-inflammatory natural products
Descriptive
TitleInfo
Title
Investigation of freshwater microalgae parachlorella kessleri as a source of anti-inflammatory natural products
Name
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NamePart
(type = family)
Villani
NamePart
(type = given)
Thomas S.
NamePart
(type = date)
1988-
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Thomas S. Villani Jr.
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author
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Jr.
Name
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NamePart
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Simon
NamePart
(type = given)
James E
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James E Simon
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Advisory Committee
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chair
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NamePart
(type = family)
Wu
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Qingli
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Qingli Wu
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
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Kimball
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(type = given)
David S
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David S Kimball
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Ho
NamePart
(type = given)
Chi Tang
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Chi Tang Ho
Affiliation
Advisory Committee
Role
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(authority = RULIB)
internal member
Name
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(type = family)
Gianfanga
NamePart
(type = given)
Tom
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Tom Gianfanga
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Advisory Committee
Role
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(authority = RULIB)
outside member
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Rutgers University
Role
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(authority = RULIB)
degree grantor
Name
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NamePart
School of Graduate Studies
Role
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school
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Text
Genre
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theses
OriginInfo
DateCreated
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2018
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2018-01
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2018
Place
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xx
Language
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(type = code)
eng
Abstract
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Considering the tremendous influence that terrestrial plants have had on the identification of bioactive molecules for the modulation of disease, it comes as a surprise that microalgae, which constitute a larger proportion of biomass on earth than terrestrial plants, have not contributed proportionally to the diverse collection of active compounds in pharmacy. As such, microalgae remain an untapped resource for new structures and activities in medicinal chemistry research. The major reason microalgae remain underrepresented in medicinal chemistry exploration is due to the difficulty of obtaining enough biomass to proceed with biochemical and toxicological evaluation of compounds contained within the biomass. Due to recent developments in aquaculture techniques, the biomass-bottleneck has been lifted, and as such, suitable microalgae for a sophisticated exploration of medicinal properties is now obtainable. Using cutting-edge culturing techniques, Parachlorella kessleri, a common freshwater microalga, was amassed in quantities sufficient to support a thorough investigation of the natural products contained within, respective to biological activities relevant to the modulation of inflammation. This investigation revealed several compounds exhibiting anti-inflammatory activity, including a known galactolipid previously unidentified in P. kessleri, and a novel oxygenated fucoxanthin ester, both compounds exhibiting significant activity in anti-inflammatory assays. This dissertation defense explores the bioactive constituents of P. kessleri with respect to anti-inflammatory properties in great detail.
Subject
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Topic
Medicinal Chemistry
Subject
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Topic
Algae
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_8650
PhysicalDescription
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electronic resource
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xxiii, 282 p. : ill.)
Note
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Ph.D.
Note
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Includes bibliographical references
Note
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by Thomas S. Villani Jr.
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T35H7KH7
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Villani
GivenName
Thomas
MiddleName
S
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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2018-01-10 14:17:52
AssociatedEntity
Name
Tom Villani
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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ETD
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windows xp
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2018-01-24T11:33:37
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2018-01-24T11:33:37
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