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Bone turnover and GLP-1 respond to a putative α-glucosidase inhibitor

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TitleInfo
Title
Bone turnover and GLP-1 respond to a putative α-glucosidase inhibitor
TitleInfo (type = alternative)
Title
Bone turnover and GLP-1 respond to a putative alpha-glucosidase inhibitor
Name (type = personal)
NamePart (type = family)
Kreitman
NamePart (type = given)
Alexandra
NamePart (type = date)
1995-
DisplayForm
Alexandra Kreitman
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Shapses
NamePart (type = given)
Sue A
DisplayForm
Sue A Shapses
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Watford
NamePart (type = given)
Malcolm
DisplayForm
Malcolm Watford
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = personal)
NamePart (type = family)
Bello
NamePart (type = given)
Nicholas T
DisplayForm
Nicholas T Bello
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2019
DateOther (encoding = w3cdtf); (qualifier = exact); (type = degree)
2019-10
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract (type = abstract)
The botanical, Salacia chinensis (SC), has α-glucosidase inhibitor (α-GI) properties that attenuates postprandial glycemic indices and increases secretion of glucagon-like peptide (GLP-1), a gut peptide that is associated with a reduced rate of bone resorption. A double-blind, placebo-controlled cross-over study was conducted to evaluate whether SC affected bone turnover and could be explained by changes in GLP-1. In this study, 21 healthy overweight/obese adults (body mass index: 29 ± 3.78 kg/m2; 21-59 years) received either placebo or SC with a fixed breakfast at each visit. A fasting blood sample was taken before and at 30-minute intervals after the meal to measure bone turnover markers as well as glycemic indices and gut peptides. Results indicated that SC attenuated the bone resorption marker, C-telopeptide of type I collagen (CTX), at 60, 90, and 120 minutes (p<0.05), and bone formation marker, osteocalcin (OC), at 180 minutes (p<0.05). In addition, SC lessened the rise in glucose compared with placebo whereas GLP-1 was increased at 60 minutes (p<0.05) with SC. Furthermore, GLP-1 and amylin were shown to be predictors of CTX. This study indicates that SC, known primarily to minimize the rise in postprandial glycemic indices, also markedly decreases postprandial bone resorption and is associated with a rise in GLP-1. Since SC attenuates postprandial bone resorption, longer term use could benefit bone health.
Subject (authority = RUETD)
Topic
Nutritional Sciences
Subject (authority = local)
Topic
GLP-1
Subject (authority = LCSH)
Topic
Glucagon-like peptide 1
Subject (authority = LCSH)
Topic
Glucosidase inhibitors
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_10343
PhysicalDescription
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vii, 43 pages) : illustrations
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/t3-nq29-ez30
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Kreitman
GivenName
Alexandra
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-09-26 15:08:52
AssociatedEntity
Name
Alexandra Kreitman
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2021-10-30
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 30th, 2021.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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ETD
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1.7
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DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-10-07T14:55:08
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-10-07T14:55:08
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