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Understanding the aggregation mechanism of ligand coated gold nanoparticles in lipid bilayers
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Ennis, Jahmal. Understanding the aggregation mechanism of ligand coated gold nanoparticles in lipid bilayers. Retrieved from https://doi.org/doi:10.7282/t3-3w4n-k034

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TitleUnderstanding the aggregation mechanism of ligand coated gold nanoparticles in lipid bilayers
NameEnnis, Jahmal (author); Griepenburg, Julie (chair); O'Malley, Sean (member); Klein, Eric (member); Rutgers University; Graduate School - Camden
Date Created2023
Other Date2023-01 (degree)
SubjectBiophysics, Nanotechnology, Computer science, Aggregation, Gold nanoaprticles, Ligands, Lipid membrane
Extent26 pages : illustrations
DescriptionGold nanoparticle aggregation is a phenomenon observed across many disciplines. We are particularly interested in the controlled aggregation of gold nanoparticles in lipid bilayers. While there has been much work done to understand the mechanism of penetration of gold nanoparticles and interactions of charged gold nanoparticle surface ligands with membranes, the mechanism of gold nanoparticle aggregation is not fully understood. A better understanding of the mechanism of gold nanoparticle aggregation can improve many fields including, but not limited to, targeted drug delivery. We use Coarse Grained Molecular Dynamics to study the mechanism of gold nanoparticle aggregation in various membrane compositions. Our results suggest that both membrane deformation and microscopic lipid deformation lead to aggregation, while ligand chain entropy acts as a balance to reduce aggregation and structure gold nanoparticle’s.
NoteM.S.
NoteIncludes bibliographical references
Genretheses
Persistent URLhttps://doi.org/doi:10.7282/t3-3w4n-k034
LanguageEnglish
CollectionCamden Graduate School Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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